The cysteinyl - containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. (science.sciencemag.org)
Specifically, AGEs cause increased vascular permeability, arterial stiffness, interfering with nitric oxide which blocks dilation of blood vessels, promoting the secretion of cytokines (chemical warfare in the body), oxidizing LDL, and raising oxidative stress (a form of rust in the body). (saragottfriedmd.com)
Swelling of the brain, resulting from increased vascular permeability and the entry of free fatty acids, reduces its circulation and oxygenation; lactic acidemia causes swelling of glial cells. (nutritionfacts.org)