Vitamin D also reduces inflammatory cytokine production in the dermal and epidermal tissue and strengthens the permeability barrier of the epidermis. (healthy-holistic-living.com)
This may be of particular importance in the ageing lung as pulmonary infections are the primary cause of morbidity and mortality in the elderly, as discussed by Boe et al. 11 Innate cells appear to have reduced TLR signalling via MAPK and NFƙB resulting in reduced inflammatory cytokine production as well as altered chemotaxis responses, decreased phagocytosis and antigen presentation capacity. (immunology.org)
Interestingly, evidence suggests that free radical and inflammatory cytokine production slow down during fasting and protective cytokine production increases and protects the brain from oxidative damage. (globalhealingcenter.com)