The name comes from the classical appearance of the round, red, raised «ring» marking the boundary of inflammatory lesions in people infected with the disease. (brittonroadveterinaryclinic.com)
«Importantly, we found necrotizing myelitis and degeneration in the spinal cord, neurodegeneration in the dorsal root ganglia, and demyelination in the nerve roots only when lymphocytic inflammatory lesions were also observed in both the central nervous system and peripheral nervous system,» stated Dr. Philipp. (sciencedaily.com)
In contrast to previous animal models of NMO that generally produced disseminated lesions, the new localized model has a single well - demarcated inflammatory lesion, allowing precise investigation of the correlation between the lesion with the deficit in motor function disrupting the corticospinal tract. (sciencedaily.com)