There are several different types of inherited metabolic disorders in dogs; the most common is von Willebrand's Disease (vWD). (darwinspet.com)
Health Problems That Can Cause Too Much Ammonia (hyperammonemia) To Be Present In Your Pet's Blood: Those issues include: Hepatic Encephalopathy, other liver problems, circulatory defects aka Portosystemic Shunts, failing kidneys, inherited metabolic disorders in the processing of protein amino acids. (2ndchance.info)
Congenital sucrase - isomaltase deficiency, a rare inherited metabolic disorder characterized by the absence or inactivity of the sucrase - isomaltase complex, results in osmotic diarrhea when sucrose is ingested because it can not be hydrolyzed. (appliedhealth.com)