However, the most obvious initial effect on the school was the resignation or early retirement of many of their better and more experienced staff. (schoolsweek.co.uk)
And as tolerance is increased, the brain begins to believe it needs more to create the same initial effect. (relevantmagazine.com)
With a final bout under his belt and a life of domestic bliss neatly laid out ahead of him, one more unexpected (and giant) hurdle reveals itself as Matty returns to the family nest and collapses, suffering the brutal initial effects of a serious brain trauma. (lwlies.com)