Most of the evidence suggests that large initial reductions in weight lead to the best long - term weight loss maintenance. (marksdailyapple.com)
(2) Unlike natural folates, which are metabolized to THF in the mucosa of the small intestine, folic acid undergoes initial reduction and methylation in the liver, where conversion to the THF form requires dihydrofolate reductase. (wellnessmama.com)
Initial reductions in caries incidence observed upon widespread implementation of these measures reached a plateau decades ago. (jcvi.org)