«These results provide an unprecedented window into the cellular dynamics of tumor evolution and suggest that interactions between subpopulations of tumor cell types contribute to metastatic progression from initial tumors,» Stanger said. (sciencedaily.com)
Partnering with the U.S. Food and Drug Administration allowed Doebele and colleagues to access clinical trial data describing initial tumor response, PFS and OS for 305 patients with stage IIIb or IV non-small cell lung cancer on trials of ALK inhibitors and 355 similar patients on trials of immunotherapies directed at PD - 1. (sciencedaily.com)
He's referring to where cells begin migrating from the initial tumor toward blood vessels, from which they can serve as seeds for new cancers throughout the body. (sciencenews.org)