Rather than tinker with the mechanics of some insulin pathway or hundreds of obscure genes, he wants to clean up all the molecular garbage that is created by normal metabolic processes (like breathing and eating) but not excreted or destroyed. (discovermagazine.com)
In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators. (sciencedaily.com)
Interestingly, the let - 7 family of micro RNA affects several key genes that regulate glucose metabolism, called the PI3 / AKT / insulin pathway.» (sciencedaily.com)