The team then tested the drug on multiple mouse models of MS.. When treated with guanabenz, mice that are genetically engineered to express high amounts of interferon gamma in their brains were protected against oligodendrocyte and myelin loss. (sciencedaily.com)
This novel intervention could be an improvement for lupus patients, as targeting interferon gamma signaling would eliminate spontaneously developed groups of B cells that produce autoantibodies and keep normal B cell responses intact to fight against infection, Rahman said. (pennstatehealthnews.org)
The study pinpoints an immune molecule called interferon gamma as the key to this link. (scientificamerican.com)