In a new study led by Tobias Sjöblom (Uppsala University / SciLifeLab), a large - scale search for genetic mutations in human colorectal cancer cells made it possible to assign additional genes to intracellular pathways of clinical importance for the disease. (scilifelab.se)
The work, published in Nature Communications, shows that LFA - 1 mediates adhesion or de-adhesion by engaging a novel intracellular pathway in T - cells. (nouvelles.umontreal.ca)
There are still kinks to work out, Liu notes — once the proteins get inside the cell, many get stuck and can't reach their targets — but this strategy has the potential to deliver monoclonal antibodies or other large proteins directly to intracellular pathways implicated in disease. (protomag.com)