The Johannes group has made two major contributions in this context: the discovery of a membrane trafficking interface between early endosomes and the Golgi apparatus, and the demonstration that dynamic protein - induced glycosphingolipid reorganization acts as a driving force for membrane invagination in clathrin - independent endocytosis. (science.institut-curie.org)
Our knowledge concerning epistatic relationships between these genes implies the existence of a poorly understood biochemical maintenance of twist expression during mesoderm invagination by the snail gene. (science.institut-curie.org)
Mesoderm invagination, the first morphogenetic movement of gastrulation in the early Drososphila embryo, is controlled by the expression of the twist and snail genes. (science.institut-curie.org)