However, because M. barkeri has a complex cell wall, produces a thick outer layer of polysaccharide, and grows in large aggregates of cells rather than as individual cells, standard RNA extraction protocols give incomplete lysis of cells and result in low yields of poor - quality RNA. (pnnl.gov)
Using immunohistochemistry and atomic force microscopy, they showed that collagen VI and Aβ form large aggregates with each other that may sequester the smaller, more toxic Aβ complexes away from neurons. (gladstone.org)
Very large aggregates can be formed from protein subunits, for example many thousand actin molecules assemble into an actin filament. (sciencedaily.com)