A hallmark of the disease is the accumulation of collagen in large nodules under the skin. (sciencedaily.com)
To his surprise, they had migrated to lymph nodes, where they grew to form large nodules that, in aggregate, reached a mass capable of keeping the animal alive. (discovermagazine.com)
About 5 % of people develop large nodules, more than a half inch across (about 1 centimeter). (hormone.org)