Prospective human mates and would - be parents who know they are carrying lethal genes may use DNA technology to avert disaster in their offspring. (howtoteachadog.com)
The strategy of targeting non-recurrently mutated synthetic lethal genes with small molecule drugs has proven to be clinically effective, as illustrated by the favorable response of BRCA1 mutant cancers to PARP inhibitors (8). (senginemedicine.com)
On the other hand, too much CIN leads to lethal gene loss and genome damage. (hubrecht.eu)