The two major constraints on development were the size of the oil market (demand) and the cost of the various phases of development (supply). (rstb.royalsocietypublishing.org)
According to him, higher costs of living, healthcare and education have added major constraints to consumer spending during the past decade. (benzinga.com)
«There are major constraints in the medication supply chain that are primarily driven by the need for strict temperature control for vaccines from the beginning to the end of the supply chain. (sciencedaily.com)