The phrase "major difference" refers to a significant or noticeable distinction between things. It highlights a big contrast or variation. Full definition
Bonds and often associated with stocks because they are both securities; however, there are a couple of major differences between the two. (gobankingrates.com)
Even slight changes in your wording can make major differences in how people react to your ad, and what action they decide to take. (inc.com)
Although both types of coverage will pay for certain parts and repairs needed for your vehicle, there are a couple of major differences in the two types of coverage. (autos.com)