The phrase "major disadvantage" means a significant drawback or a big problem that puts someone or something at a clear disadvantage compared to others. Full definition
Fresh meat sources are highly desirable but one major disadvantage of using them as dog food ingredients is their high water content (about 80 %). (dogfoodchat.com)
Conventional wisdom holds that smaller private owners face major disadvantages in the REIT - dominated world of leasing. (nreionline.com)
Security and scam appear is the two major disadvantages for this reason the organization has written articles to assist people date securely. (uberant.com)