The phrase "major hub" refers to a central location or place that serves as a key point of connection or activity. It is an important and busy place where people, goods, or information can flow in and out easily. Full definition
Virgin was focused on transit between major hubs and didn't have its own network of regional jets to feed passengers into the larger cities. (rewardexpert.com)
The Mohawk Valley is on its way to becoming the state's second major hub for nanotechnology, and will play a major role in Governor Cuomo's vision to establish a Nano Canal Corridor that stretches from Albany to Buffalo.» (ocgov.net)