The phrase "major limitation" refers to a significant or important constraint or drawback that hinders or restricts something or someone from functioning fully or effectively. Full definition
The only major limitation of this document storage that I found is that you can't upload pictures, videos and audio files. (rocketlawyer.com)
But the review also found major limitations in the amount and quality of the evidence — particularly in terms of identifying the safest and most effective combinations of medications and psychosocial treatments. (sciencedaily.com)
The catch: despite great performance, there are still a few major limitations. (gizmodo.com)