The phrase "major ramifications" means that an action or decision will have significant consequences or effects. It suggests that the outcome will have a great impact on the situation or people involved. Full definition
Additionally, if a diabetic is not properly managing their disease, magnesium may be depleted, which has major ramifications in insulin resistance. (amazon.com)
This could have major ramifications on insurance rates, because the cost and labor associated with repairs for a customized bike can be quite high. (valuepenguin.com)
Huge matchup early in the season that could potentially have major ramifications down the road. (allsportsseries.com)