"Mammary tumorigenesis" refers to the process of the development and formation of tumors or abnormal growths in the breast tissue. It specifically focuses on the creation and progression of cancerous cells in the mammary glands. Full definition
Interestingly, Yu and colleagues recently showed that knockdown of KLF4 decreased the proportion of cancer stem cells, whereas overexpression of this gene led to an increase in the cancer stem cell population, suggesting that KLF4 plays a strong oncogenic role in mammary tumorigenesis likely by maintaining stem cell - like futures of breast cancer cells (29). (cancerres.aacrjournals.org)
Lozy F, Cai - McRae X, Teplova I, Price S, Reddy A, Bhanot G, Ganesan S, Vazquez A, Karantza V. ERBB2 overexpression suppresses stress - induced autophagy and renders ERBB2 - induced mammary tumorigenesis independent of monoallelic Becn1 loss. (cinj.org)
In Nrk mutant mice, therefore, mammary tumorigenesis was proposed to be triggered by a combination of dysregulation of proliferation in mammary epithelial cells and excessive blood estrogen. (sciencedaily.com)