The research will also move forward understanding of the relationship between genetic characteristics and anaesthetic requirements, he says: «Investigating the role of melanocortin system in the central nervous system is likely to help us understand fundamental questions such as which systems in the brain produce unconsciousness and which modulate pain perception.» (newscientist.com)
Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin - 4 receptor polymorphisms identified in obese humans. (semanticscholar.org)
Administration of SHU9119, a potent melanocortin receptor antagonist, selectively in the PVN of PrcpAgRPKO male mice increased food intake to a level similar to that of control mice. (molecularmetabolism.com)