Our research showed that the FOXO4 gene normally turns off genes that control specific metastatic behavior in malignant tumor cells, such as the ability to invade tissues and then to survive and multiply there,» says Dr. Gelman, the John & Santa Palisano Chair in Cancer Genetics at RPCI. (sciencedaily.com)
The research program is based on three central themes: A) Investigating the molecular mechanisms of tumor cell migration, B) Evaluating and validating the contribution of these mechanisms to metastasis in cancer patients C) Developing research and clinical tools to investigate metastatic behavior of tumor cells. (vicc.org)
Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors. (ptglab.com)