The phrase "metastatic sites" refers to the places where cancer cells have spread from their original location to other parts of the body. Full definition
Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD - L1 expression by quantitative immunofluorescence. (jcancer.org)
Not surprisingly, the PD - L1 expression was significantly higher in metastatic sites compared to the nephrectomy cores (P < 0.05). (jcancer.org)
Patients often have available tissue blocks from nephrectomy specimens, but not from metastatic sites for analysis of biomarker expression, yet metastatic specimens are typically treated with systemic therapy, after nephrectomy. (jcancer.org)