The team undertook a series of experiments to define the role of miR -17-92 in regulating T - and B - cell pathogenicity using murine models of allogeneic BMT, including models of scleroderma that had transitioned from aGVHD to cGVHD, classic cGVHD scleroderma, lung inflammation and a lupus - like condition. (sciencedaily.com)
Significant binding by miR -124-3p to two of the potential target genes was seen, as measured from immunoprecipitated RNA - induced silencing complexes. (sciencedaily.com)
Four of these potential target genes were significantly down - regulated in the prefrontal cortex of corticosterone - treated rats, and this down - regulation inversely correlated with miR -124-3p levels. (sciencedaily.com)