By contrast, not a single one of 25 colorectal patients lacking mutations in mismatch repair genes responded. (sciencemag.org)
The majority of cases of Lynch syndrome are attributed to heterozygous germline mutations in the DNA mismatch repair genes MLH1 and MSH2, and current methods for DNA sequencing and deletion analysis can successfully detect these mutations. (sciencedaily.com)
They quickly identified an equivalent mismatch repair gene in humans. (newscientist.com)