Interestingly, two studies of melanoma cell lines revealed frequent mutations in mitogen activated protein (MAP) kinase kinase [kinase] genes MAP2K1, MAP2K2, MAP3K5, and MAP3K9. (massgenomics.org)
One such checkpoint pathway is modulated by an enzyme called p38 mitogen - activated protein kinase (MAPK), whose activity is known to disrupt the cell cycle. (sciencedaily.com)
An IRF -1-dependent pathway of DNA damage - induced apoptosis in mitogen - activated T lymphocytes. (nature.com)