Sources familiar with the new work from Mitalipov's group told the MIT Technology Review that they had produced tens of successfully edited embryos, and had avoided the issue of mosaicism by injecting eggs with CRISPR right as they were fertilized with donor sperm. (sciencemag.org)
There's a very interesting session on mosaicism in human disease (session 12), but I expect I'll spend most of my time in session 10, Disease Gene Discovery Strategies. (massgenomics.org)
Scientists are also exploring the consequences of an unusual feature of imprinting disorders like Beckwith - Wiedemann: Only some of the body's cells are abnormal, a phenomenon known as mosaicism. (sciencemag.org)