To the best of our knowledge, there have been limited in vivo human studies assessing intracellular regulation of skeletal muscle protein metabolism in response to negative energy balance. (academic.oup.com)
Regardless of whether energy deficit is induced by energy restriction, increased energy expenditure, or a combination, varied measures of whole - body and skeletal muscle protein metabolism indicate that consuming dietary protein in excess of the RDA confers a level of protection for skeletal muscle integrity. (academic.oup.com)
Aerobic exercise overcomes the age - related insulin resistance of muscle protein metabolism by improving endothelial function and Akt / mammalian target of rapamycin signaling. (ironmanmagazine.com)