Subsequently, another 65 German Shepherds were tested in order to determine the frequency of mutant alleles in this breed. (journals.plos.org)
A clustering analysis of mutant allele frequencies suggested that there were four clones (tumor subpopulations) in the primary tumor defined by distinct sets of mutations. (massgenomics.org)
Although phenotypic consequences, referred to here as biallelic effects, resulting from two different mutant alleles in compound heterozygote patients have been postulated, such effects have historically been difficult to distinguish from the influence of environment and genetic background. (journals.plos.org)