"mutational signatures" refer to specific patterns or types of changes in the DNA of an organism. These patterns can help scientists understand the causes and potential effects of genetic mutations. Full definition
«Use of CRISPR - modified stem cell organoids to study the origin of mutational signatures in cancer» (agbt.org)
Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78 % showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes. (stm.sciencemag.org)
Mutational signatures reveal high burdens of aristolochic acid — related mutations in Asian liver cancers, with Taiwan most intensely affected. (stm.sciencemag.org)