The dynamic of the relationship provides negative regulation by «making them» push harder or run faster. (sanfranciscomarriagecenter.com)
Honda, K., Mizutani, T. & Taniguchi, T. Negative regulation of IFN - α / β signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells. (nature.com)
Arrows indicate positive regulation while hash - marks indicate negative regulation; dashed lines indicate putative interaction. (cellr4.org)