The phrase "neoadjuvant setting" means the use of treatment, such as chemotherapy or radiation therapy, before the primary treatment. This is done to shrink a tumor or cancer before surgery or other main treatments are given. Full definition
Though trastuzumab and pertuzumab have increased response rates and improved outcomes in HER2 - positive breast cancer, 30 % to 40 % of early - stage patients treated in the neoadjuvant setting will have residual disease at the time of surgery. (cancernetwork.com)
Cardiac effects of pertuzumab and trastuzumab following chemotherapy in the neoadjuvant setting were limited for HER2 - positive breast cancer patients. (cancernetwork.com)
Addition of bevacizumab to standard chemotherapy in the neoadjuvant setting in patients with HER2 - negative metastatic breast cancer improves progression - free survival and the proportion of patients achieving pathological complete response. (science.institut-curie.org)