"Neuronal damage" refers to harm or injury to the cells in our brain and nervous system called neurons. This damage can disrupt the normal functioning of these cells, leading to various problems in the brain and body. Full definition
Bettcher also emphasized that although participants had detectable levels of AD - related markers and markers of neuronal damage in their CSF, the presence of these markers alone does not indicate a diagnosis of AD, nor does it mean that they will develop AD in the future. (sciencedaily.com)
Signs of neuronal damage around plaques also varied depending on the APOE variant the animals received, and experiments in a different Alzheimer's model in which plaques appear more slowly showed that injection of APOE4 increased levels of free, soluble A-beta in the fluid that bathes the brain. (sciencedaily.com)
In other words, the researchers determined that modulating the mouse brain's stress circuitry (without actually changing the normal response) mitigated generation and accumulation of amyloid plaques widely attributed with causing neuronal damage and death. (sciencedaily.com)