Together, our results identify SCYL1 as a key regulator of motor neuron survival, and Scyl1 -LRB-- / --RRB- mice share pathological features with many human neurodegenerative conditions. (emdmillipore.com)
(B) Analysis of neuron survival within laminae immediately adjacent to the site of injury shows that hGDABMP transplantation promoted significant protection of neurons when all laminae were considered (4 to 9), with the most robust increases in neuron numbers in intermediate (7) and ventral (8 and 9) gray matter laminae. (journals.plos.org)
More broadly, the research suggests a new framework for exploring how the mutated proteins interfere with normal processes for neuron survival in other neurodegenerative diseases. (sciencedaily.com)