When they selectively eliminated supporting cells in newborn mice, nearby cells rapidly replaced them, thereby preserving hearing. (science.sciencemag.org)
A crucial aspect of the mouse model development was the ability to use what's called the «Sleeping Beauty» technique of inserting genes into stem cells in the brain of newborn mice. (uofmhealth.org)
Their method relied on briefly bathing blood cells from newborn mice in a mildly acidic solution and then tweaking culture conditions to produce stem cells. (sciencemag.org)