The genetics of brain disorders are complex, in that multiple genes interact with a host of nongenetic factors to determine an individual's risk. (sciencemag.org)
No major gene variances were obtained for HD from the shuffled data sets, and thus it can be considered likely that evidence of major genes was unlikely to have been a spurious result caused by nongenetic effects. (nature.com)
The work is among the first to show a link between nongenetic signals and the asymmetric expression of genes, says computational biologist Nick Monk of the University of Sheffield, U.K.. (sciencemag.org)