Your ability to grapple and attack enemies from a distance while still moving to avoid other dangers along the way is what ultimately allowed players to defeat Ninja Gaiden's many challenges, but the game's notorious difficulty made those moments of victory more rewarding as a result. (snackbar-games.com)
Initiatives that have focused on building revenue through tourism have had notorious difficulty passing money down to people in the community. (treehugger.com)
But the invasive nature of the treatment, and the notorious difficulty in translating neuropsychiatric research from animal models to humans, could complicate its path to the clinic. (scientificamerican.com)