Although we can not identify a single PB for novel entities (here defined as new substances, new forms of existing substances, and modified life forms that have the potential for unwanted geophysical and / or biological effects), they are included in the PB framework, given their potential to change the state of the ES. (science.sciencemag.org)
Despite ongoing efforts toward finding novel entities for the treatment of the most challenging cancers, translation into patient benefit has been slow due to the fact that translational cancer research from early drug discovery to late stage drug development and assessment in clinical trials is a long process. (amsbio-oncoscreen.com)
Although we can not identify a single PB for novel entities (here defined as new substances, new forms of existing substances, and modified life forms that have the potential for unwanted geophysical and / or biological effects), they are included in the PB framework, given their potential to change the state of the ES. (science.sciencemag.org)