O'Sullivan came to the Karlseder lab seven years ago to explore whether histone / DNA interactions in nucleosomes altered telomere function. (sciencedaily.com)
Chromatin is built when DNA winds around millions of spool - like protein structures called nucleosomes. (scientificamerican.com)
Using super-resolution fluorescence microscopy (stochastic optical reconstruction microscopy; STORM)(Rust et al., Nature Methods, 2006) in collaboration with the group of Melike Lakadamyali (Institute of Photonic Sciences, Barcelona) we have dissected out the nanoscale organization of nucleosome assembly, with high molecular specificity and spatial resolution in a variety of somatic and stem / reprogrammed cells. (piacosmalab.com)