Knowing more about how enhancers and eRNAs function will help oncologists, since recent DNA sequencing of tumors from humans show that numerous mutations associated with cancers and other diseases occur in enhancer regions of the genome — not in protein - coding regions. (sciencedaily.com)
«This is a very easy target for natural selection,» Wrangham argues, because it probably does not depend on numerous mutations but rather on the tweaking of one or two regulatory genes that determine the timing of a whole cascade of developmental events. (discovermagazine.com)
«We wanted to understand why numerous mutations accumulate in cells with activated oncogenes,» explains Thanos Halazonetis, Professor at the Department of Molecular Biology of the UNIGE Faculty of Science. (sciencedaily.com)