In their models, abatacept reduced the proliferation and activation of effector T cells. (sciencedaily.com)
Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing. (btiscience.org)
c - Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. (cancerresearch.org)