«Our discovery of germline mutations in so many cases of Wilms tumor means that the children and family members of these patients may be at risk for tumor development,» said Perlman. (sciencedaily.com)
PLZF is expressed in germline stem cells and is required for their self - renewal. (jax.org)
Carriers of germline mutations in BRCA2 have at least five times greater risk of prostate cancer and frequently develop a more aggressive form of the disease. (cancerresearchuk.org)