After 10 stages you'll face off against one of the game's 4 bosses, and while none of them are particularly memorable (besides the unusually named second boss), they do a good job of breaking up the game's usual rhythm of just blasting away at waves of enemies. (miketendo64.com)
Approximately one out of every 20 people in the course of his or her life suffers an epileptic attack, during which the nerve cells get out of their usual rhythm and fire in a very rapid frequency. (sciencedaily.com)
In epilepsy, nerve cells or neurons lose their usual rhythm, and ion channels, which have a decisive influence on their excitability, are involved. (sciencedaily.com)