The improvement of visual acuity in sham - treated eyes was unexpected based on the natural history of LHON, for which partial spontaneous recovery is reported in only 8 to 22 % of patients with the G11778 ND4 mutation (Lam et al. 2014, Riordan - Eva et al. 1995). (gensight-biologics.com)
Both hNPCctx — GDNF and hNPCctx transplant recipients were included in the cell - injected group, which consisted of a select population of eyes that displayed superior performance on spatial visual acuity testing. (journals.plos.org)
Meta - analysis of three RCTs showed significant benefit for sweep VEP acuity at 12 months (log of the minimum angle of resolution (logMAR)-RRB-(mean difference (MD)-0.15, 95 % confidence interval (CI)-0.17 to -0.13; I2 = 0; three trials; N = 244), but meta - analysis of three other RCTs showed no benefit for visual acuity measured with Teller cards at 12 months (cycles / degree)(MD -0.01, 95 % CI -0.12 to 0.11; I2 = 0; three trials; N = 256). (cochrane.org)