While some animal studies had concerns about early onset of puberty, development of breast tissue, or thyroid cancer, this has not been proven as an issue in humans in those studies. (myorganicformula.com)
I have worried before that stopping the normal onset of puberty in boys who believe they are girls, is a form of human experimentation — and on children, no less. (firstthings.com)
Their usual onset of puberty is when they are eight or nine years of age. (boba.com)