For instance, oral estrogen replacement is processed first through the liver. (ashcenter.com)
SHBG is not a useful test, however, if a woman is taking oral estrogen replacement therapy, because this estrogen will artificially elevate SHBG due to high estrogen levels in the liver. (holtorfmed.com)
And for some women, doctors may prescribe vaginal estrogen, which eases symptoms without putting as much estrogen in your bloodstream as oral estrogen treatments. (health.com)