For example, if you want to transpose the function of a protein in a model organism to the corresponding human protein, you can make use of orthology to detect the right protein. (sciencemag.org)
Most orthology determination methods make use of sequence comparisons: the amino acid sequences of all proteins in two species are compared with each other, and the two sequences that are most similar are considered to be orthologs. (sciencemag.org)
The aim of my research is to use several methods that determine protein orthology (common ancestor) relationships and test which one can be best used for prediction of protein function. (sciencemag.org)