BLU - 667 works by inhibiting the activity of RET, and it was chosen for further study after it was found to be 100 times more selective for RET, meaning it shouldn't affect the functions of other kinases. (newatlas.com)
This is a very important lipid, that actually is involved in signaling, to many other kinases, and the key kinase that through this pathway gets activated is Akt; and Akt is a very important kinase that regulates many other factors. (abcam.com)
«Most importantly, they were in positions of the kinase domains predicted to alter function, based on analogous mutations that have been seen before in other kinases,» he said. (hhmi.org)