The Clock mutants were also shown to exhibit reduced overall expression levels and a blunted diurnal rhythm of orexin mRNA, a hypothalamic neuropeptide involved in energy regulation (2). (academic.oup.com)
By slightly changing these master genes, evolution could have an outsized effect on overall expression without as much chance of negative mutations, Gilad says. (scientificamerican.com)
We first analyzed the overall expression distribution for each class of receptors in their cognate tissue. (journals.plos.org)